A New One-Pot Three-Component Synthesis of 4-Aryl-6-cycloamino-1,3,5-triazin-2-amines under Microwave Irradiation

Abstract A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction presence hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into targeted compounds via dehydrogenation alkali. tolerated various aldehydes (including heterocyclic) Crystal structures two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines established by X-ray crystallography. results preliminary biological screening identified potent antileukemic activity 6-[3,4-dihydroisoquinolin-2(1H)-yl]-4-phenyl-1,3,5-triazin-2-amine.